When Kendrick Lamar was announced as the halftime performer for Sunday’s 2025 Super Bowl in New Orleans, Lil Wayne took to his Instagram Live to share that he felt snubbed that he wouldn’t get the opportunity to be the headliner in his own hometown.
This sensitivity became the inspiration for a collaboration with skincare brand Cetaphil in a playful Super Bowl ad, titled “We’re all a Lil Sensitive.” The commercial starts with Lil Wayne receiving some disappointing news. He is at first crushed, but asks for Cetaphil. The lotion, known for treating sensitive skin, re-energizes him and allows him to help heal others in various comedically sensitive emotional situations.
Lil Wayne stars in a 2025 Super Bowl ad for Cetaphil.
Ben Ottewell / Courtesy of Cetaphil
There’s also a cameo from Dr. Muneeb Shah, a dermatologist influencer and founder of Remedy Skin.
Throughout the commercial, Lil Wayne teases his new album, “Carter VI.” Actors in the ads wear jerseys with the number 06, 06 and 25, and the commercial ends with a door displaying a sign that reads “Do not disturb ’till 06-06-25, Carter VI.”
Last year’s Cetaphil ad was a commercial inspired by Taylor Swift’s and Travis Kelce’s relationship. The commercial, titled “Game Show Glow,” was about how Swift influenced dads and daughters to watch football together on Sundays.
Lil Wayne stars in a 2025 Super Bowl ad for Cetaphil.
Courtesy of Cetaphil
In addition to Lil Wayne’s chart-topping music, the rapper is known for his head-turning fashion statements. He was one of many celebrities that embraced the red Mschf boot trend. He was photographed behind the scenes for a music video wearing the Brooklyn brand’s sold-out boot that was inspired by the Japanese video game and anime character Astro Boy.
Lil Wayne previously had his own apparel line Trukfit, which stood for “The Reason You Kill For It.” It debuted in 2012, with wild designs that almost parodied Japanese streetwear.
